Lisuride (brand name Dopergine and others) is a Parkinson's medication, which, like all Parkinson's medications enhances the presence and/or activity of the neurotransmitter dopamine in the human brain. In many instances, enhanced dopamine functionality has been associated with increased sexual appetite and better sexual performance.

I decided to try lisuride after a friend and reader reported a positive experience with lisuride. The reader described his experience as follows:

"Lisuride: I tried this after reading about it in the book Sexual Pharmacology. It is available in Europe. A friend got some from France. It is an ergotic dopaminergic drug, mainly used for Parkinson's disease. The packet insert lists impuissance (impotence) as another indication. It has a real effect. It increases desire and sensitivity. It also causes nausea."

So far the reader's experience.

I myself got some lisuride (Dopergine) in Thailand where most prescription medications are sold over the counter. I have also tried a number of dopamine medications for their alleged capability to enhance sexuality. I have had good effects with some of them, though during my early experiments with dopamine agonists, I made clear mistakes in the way I ingested them. As a result, nausea has always been a problem. (Part 3 of this series of articles on lisuride deals with the correct way to ingest dopamine agonists for sexual enhancement.)

Parkinson's medications can be quite powerful in unpleasant effects if taken by people who are not Parkinson's patients. So I started my lisuride experiment with just a quarter of a tablet, not combining it with anything else.

It didn't have much of a sexual effect, but I experienced a fit of anger that lasted for hours and wasn't very pleasant for my social environment. I don't know, though, to what extent to blame the lisuride. Anger hasn't been much of a problem in further lisuride experiments. But there were others.

In my next experiment I tried half a tablet of lisuride, combined with nothing else, and I felt absolutely lousy. I had to lie down right from the moment I felt the lisuride kicking in, and I had to stay in bed for the whole day. Thank God it was Sunday and I didn't have any urgent work to do.

I didn't develop any fever, or other measurable symptoms such as increased heart rate. I just felt lousy, as if I wanted to vomit, tough I didn't reach that point.

I know this kind of nausea from a few years ago. From the mid-twenties on, for several years, I terribly suffered from migraines. It would be an understatement to call them migraine headaches, as these attacks really effected the whole body, including being nauseated to the point of vomiting.

I want to relate more on these migraine states, because of their similarity to what I experienced under lisuride.

While those migraine attacks were unpleasant to the extreme, I usually could escape the discomfort by lying down to sleep. This option obviously was available only when I didn't have to work. It was, therefore, good timing if I had my migraine attacks on Sundays, and indeed, for months on end, I suffered from migraine every Sunday, so I just spent these days in bed, sleeping along. In order to clarify that my headaches really were migraines, I shall describe them briefly. I usually experienced migraine attacks when I was very relaxed (on those free Sundays I learned to hate). On high-stress days, I seldom experienced migraine attacks.

Usually, when it occurred to me, that, shit, I was very relaxed, the first measurable symptom wasn't far away. I would lose vision. I would lose vision gradually over some ten to fifteen minutes. It would start with my vision becoming glassy on the edges (distorted as if one looked at the world through the bottom of a cheap drinking glass. Over the period of about five minutes, this glassiness would move to the center of vision. The vision would then change to a full blackout. Very soon thereafter, I would regain vision from the edge. This resulted in funnily distorted perceptions. I could, for example, sit directly opposite a person and see everything surrounding us at the edges, but I wouldn't see the person directly in front of me.

I possess a good portion of distrust for the medical establishment, and I would say, luckily so. Otherwise I just could have gotten into the hands of some mad psychiatrist who would have diagnosed my vision distortions as hallucinations based on some specific sub-type of schizophrenia, and I would have passed my days as a heavily sedated patient in a psychiatric institution.

Obviously, I was worried about my migraines particularly in the months after they first occurred. I wondered whether I had a strange brain disease or maybe just an ordinary head tumor, which would rob this young promising journalist of his future, and his beautiful girlfriend of the best love maker she ever would have.

Am I really so convinced of my sexual prowess at that time? Maybe. Maybe not. Maybe it's just for the impact I wish this essay will have on the reader. Maybe I just want to recommend to young pretty women that they find themselves a migraine sufferer if they want to experience great sex. Anyway, I'm wholeheartedly convinced that there exists a strong relationship between dopamine and migraine headaches. I would even go as far as postulating the hypothesis that migraines are a direct result of hyper-dopaminergic events in the brain, and that, while migraine attacks surely are unpleasant, migraine sufferers are also likely to get the best out of their sex lives.

I base this assessment on ample personal experience with migraines, as well as in the horizontal position. At the time I was super sick with migraines, I was also super healthy, sex-wise. This was a time when I could come up with a world-class erection out of the blue by just focusing my though on a girl I saw a little while ago. There was a time when I could maintain a world-class erection for half an hour or an hour just by daydreaming about some past or imagined sexual encounters. It was a time when I could willfully produce an ejaculation by just applying a strong grip to that organ that rightfully is called vital.

I am convinced that a strong relationship exists between migraines and dopamine activity, and over the years I have come across a good number of indications that this is the case, without first actually recognizing the proof. Please see part 2 of this series for details.